A gene implicated in operant learning finally discovered

Till now, most of the research on learning at the molecular level or LTP/TLD has focused on classical conditioning paradigms. To my knowledge for the first time someone has started looking at whether , on the molecular level, classical conditioning , which works by associations between external stimuli, is differently encoded and implemented from operant learning , which depends on learning the reward contingencies of one's spontaneously generated behavior.

Bjorn Brembs and colleagues have shown that the normal learning pathway implicated in classical conditioning, which involves Rugbata gene in fruit fly and works on adenylyl cyclase (AC) , is not involved in pure operant learning; rather pure operant learning is mediated by Protein Kinase C (PKC) pathways. This is not only a path breaking discovery , as it cleary shows the double dissociation showing genetically mutant flies, it is also a marvelous example fo how a beautiful experimental setup was convened to separate and remove the classical conditioning effects from normal operant learning and generate a pure operant learning procedure. You can read more about the procedure on Bjorn Brembs site and he also maintains a very good blog, so check that out too.

Here is the abstract of the article and the full article is available at the Bjorn Brembs site.

Learning about relationships between stimuli (i.e., classical conditioning ) and learning about consequences of one’s own behavior (i.e., operant conditioning ) constitute the major part of our predictive understanding of the world. Since these forms of learning were recognized as two separate types 80 years ago , a recurrent concern has been the
issue of whether one biological process can account for both of them . Today, we know the anatomical structures required for successful learning in several different paradigms, e.g., operant and classical processes can be localized to different brain regions in rodents [9] and an identified neuron in Aplysia shows opposite biophysical changes after operant and classical training, respectively. We also know to some detail the molecular mechanisms underlying some forms of learning and memory consolidation. However, it is not known whether operant and classical learning can be distinguished at the molecular level. Therefore, we investigated whether genetic manipulations could differentiate between operant and classical learning in dorsophila. We found a double dissociation of protein kinase C and adenylyl cyclase on operant and classical learning. Moreover, the two learning systems interacted hierarchically such that classical predictors were learned preferentially over operant predictors.

Do take a look at the paper and the experimental setup and lets hope that more focus on operant learning would be the focus from now on and would lead to a paradigmatic shift in molecular neuroscience with operant conditioning results more applicable to humans than classical conditioning results, in my opinion.



B BREMBS, W PLENDL (2008). Double Dissociation of PKC and AC Manipulations on Operant and Classical Learning in Drosophila Current Biology, 18 (15), 1168-1171 DOI: 10.1016/j.cub.2008.07.041

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Blog Action Day: Poverty and IQ: from the archives

Well, today is blog action day 2008, and the topic for today is Poverty.

I am afraid I will be posting one of my old posts today: a post relating Poverty and SES to IQ and I am also publishing some relevant comments as the comment length generally exceeded the article length:-):

The post, comments and my response to comments are as follows; I would love to rekindle debate on SES/Poverty and IQ again and am looking for more discussions. Also please check out this earlier post on the simillar poverty and IQ topic:

Original Post: Is low IQ the cause of income inequality and low life expectancy or is it the other way round?

As per this post from the BPS research digest, Kanazawa of LSE has made a controversial claim that economic inequality is not the cause of low life expectancy, but that both low life expectancy and economic inequality are a result of the low IQ of the poor people. The self-righteous reasoning is that people with low IQ are not able to adapt successfully to the stresses presented by modern civilization and hence perish. He thinks he has data on his side when he claims that IQ is eight times more strongly related to life expectancy, than is socioeconomic status. What he forgets to mention(or deliberately ignores) is growing evidence that IQ is very much determinant on the socioeconomic environment of its full flowering and a low IQ is because of two components- a low genetic IQ of parent plus a stunted growth of IQ/intelligence due to impoverished environment available because of the low socio-economic status of the parents.

A series of studies that I have discussed earlier, clearly indicate that in the absence of good socioeconomic conditions, IQ can be stunted by as large as 20 IQ points. Also discussed there, is the fact that the modern civilization as a whole has been successful in archiving the sate of socioeconomic prosperity that is sufficient for the full flowering of inherent genetic IQ of a child and as such the increments in IQ as we progress in years and achieve more and more prosperity (the Flynn effect) has started to become less prominent. This fact also explains the Kanazawa finding that in 'uncivilized' sub-Saharan countries the IQ is not related to life expectancy, but socio-economic status is. although, he puts his own spin on this data, a more parsimonious ( and accurate) reason for this is that in the sub-Saharan countries, even the well -of don't have the proper socio-economic conditions necessary for the full flowering of IQ and thus the IQ of both the well-off and poor parents in these countries is stunted equally. Thus, the well-off (which are not really that well-off in comparison to their counterparts in the western countries) are not able to be in any more advantageous position (with respect to IQ) than the poor in these countries. The resultant life expectancy effect is thus limited to that directly due to economic inequality and the IQ mediated effect of economic inequality is not visible.

What Kanazawa deduces from the same data and how he chooses to present these findings just goes on to show the self-righteous WASP attitude that many of the economists assume. After reading Freakonomics, and discovering how the authors twist facts and present statistics in a biased manner to push their idiosyncratic theories and agendas, it hardly seems surprising that another economist has resorted to similar dishonest tactics - shocking people by supposedly providing hard data to prove how conventional wisdom is wrong. Surprisingly, his own highlighting of sub-Saharan counties data that shows that life-expectancy is highly dependent on socio-economic conditions in these countries is highly suggestive of the fact that in cultures where the effects og economic inequality are not mediated via the IQ effects, economic inequality is the strongest predictor of low life expectancy.

Instead of just blaming the people for their genes/ stupidity, it would be better to address the reasons that lead to low IQs and when they are tackled, directly address the social inequality problem , as in the author's own findings, when IQ is not to blame for the low life expectancy, the blame falls squarely on economic inequality (as in the sub-Saharan countries data) .

7 comments:

Asterion said...

First of all, I beg you pardon for my limited english.
I find quite interesting your findings. But there could be an issue which limits the reasoning: how the IQ is meassured? or what does it really meassures? Does it really defines how smart or clever a person is?
I think there must be a lot of denounces about it. So, I think it's important to recognize the limits of this aproach based on IQ meassurment limitants. Of course, there could be a reference in your and Kanazawa's articles (I have not seen none of them).
All of this is beacuse I have met childs quite smarts living in the poorest zones of my city (Bogotá,
Colombia), I would say all of them seems to be quite smart, at least form my point if view. They are all really quick undertanding abstract problems and linking things. I think they have a strong capability to analize any situation. So, if you are able to meassure their IQ using problems wich need, for instance, to apply Phitagora's theorem, surelly they will be in trouble. So I think education could explain better economic inequalities and, thus, low life expentacy.
I never have explored this issue, so I would thank you refering me to some relevant literature related. Even telling me if I am quite wrong or not.

Always learning...


Sandy G said...

Hi Julian,

I appreciate your thoughtful comments. It is true that intelligence consists of a number of factors (as large as 8-10 broad factors), and is also differentiated as crystallized(Gc) and fluid (Gf); but for most analysis a concept of a general underlying common factor , spearman's g, is taken as reflective of intelligence and measured by the IQ scores.

In this sense, IQ/g does reflect how clever or smart a person is, but success/outcome in life is affected by other factors like motivation, effort, creativity etc.

I agree that many children in impoverished environments are quite smart, but you would be surprised to discover how providing an enriched environment to them, at their critical developmental periods,would have resulted in lasting intelligence gains. They are smart, but could have been smarter, if they had the right socioeconomic environment. On the other hand, an average child from well-to-do family would be able to maximally develop its inherent capabilities and thus stand a stronger chance than the poor smart child, whose capabilities haven't flowered fully.

Cultural bias in IQ measures have been found in the past, but the field has vastly improved now and these biases are fast disappearing leading to more accurate and valid cross-cultural comparisons.

The key to remember here is that poor socio-economic condition affects longevity via multiple pathways- one of them is direct by limiting access to good health care and nutrition, but there are also indirect effects mediated by , as you rightly pointed, education (poor people get less education and not vice versa) and also intelligence.

Garett Jones said...

Two words: East Asia.

If bad social and economic outcomes were the key driver of low IQ, then we'd expect East Asians to have had low IQ's back when they were poor--say, back in the 50's and 60's. Check out Table 4 of my paper (page 28) to see if that's the case...

http://mason.gmu.edu/~atabarro/iqprodprelim.pdf

Guess not. So, East Asians have been beating Causasians on IQ tests (on average) for as far back as we have data. You can get more historical data along these lines from Lynn's (2006) book, Race Difference in Intelligence.

And one can go even further back if you look at brain size, which correlates about 0.4 with IQ. Asian brains have been well-known to be larger than Caucasian brains for as long as folks have been measuring both of them. Hard to fit that in with WASP-driven science...

So simple reverse causality surely plays some role, but it can't explain East Asia.....

Sandy G said...

Hi Garret,

Thanks for dropping by and commenting.

I guess we agree on more things, than we disagree on. For example, in section IID of your paper, you concur with my explanation of Flynn effect that it is most probably due to the increase in living conditions and due to environmental factors enabling the full flowering of potential. Environment can and does have a strong disruptive negative effect, though it only has a limited positive enabling effect (no amount of good environment can give you an intelligence that is disproportionate to what your genes endow on you; but even minor lack of right environmental inputs or toxins, can lead to dramatic stunted achievement of that potential intelligence).

Also, it is heartening to note, that early on in your paper you take the position that your paper will not settle genetic vs environmental debate on IQ, but would only provide evidence that national IQ is a good indicator of ntaional productivity.

I have no issue with the same and agree that if one disregards the process by which adult stable IQs are archived, then the stable adult IQ that has been archived would be a very good predictor of productivity and economic status (in a free market environment where other conditions re not adversely affecting success). There is no qualms with the causal relation between a better IQ leading to better SES, in a fair world.

What I do strongly disagree with is the assumption that low IQ is solely dependent on genetic factors. Bad socio-economic factors are the key drivers of low IQ- especially in situations where the socio-economic status is so low that it does'nt guarantee access to basic amenities of life like proper nutrition/ health care.

It is interesting to note that poor SES would cause stunted growth of IQ, and due to the causal relation between IQ and SES would lead to less productivity and lower income, thus maintaining or even aggravating the low SES. This is the downward vicious cycle from which it is very hard to emerge. This type of economy and culture would definitly have lower IQ than what could have been achieved in the right conditions. The sub-saharan countries that Kanazawa used in his study, match this pattern and some of the African countries National IQ (as per data appendix in your paper) viz. Kenya: 72, south afric: 72, ghana : 71 confirms to this pattern).

The opposite observation, that a spiraling economy should radically lead to high IQs is not reasonable, as the circle is vicious only in the downward direction. Monumental leaps in SES would not lead to dramatic effects in IQ, if the earlier SES levels were just sufficient to ensure that no negative effects of environment come into play. The Flynn effect is a tribute to the fact that high jumps in SES (above the base level) only lead to small incremental changes in IQ.

Another thing to keep in mind is that when the SES to low IQ causal link is suggested it is only for the achievement of the stable adult IQ and instrumental during the critical childhood developmental periods. Although, environmental toxins do have the capability to adversely affect IQ during adulthood, and there is emerging evidence for plasticity and neurogenesis in adulthood, a simpler and reasonably model is whereby adult IQ is stable and not much affected by SES changes (either up or down) once it has been stabilized. Thus, even if some positive effects of rising SES have to be observed, they would be observable only in children exposed to that SES and not in the IQ of the rest of the adult population, that has already acheived a stable IQ.

Thus, I do not agree with your explanation of the east Asian example. To me the data set appears to be very limited ( no IQ results before the 1950's; no data sets for the same country or population over time) and even if we assume that only after the 1980s the SES of these countries rose above the minimal needed SES, we still do not have the data for the IQ of children born under theses SES condition, to proclaim that ther eis no rise in IQ.

Further, it is quite plausible that productivity is dependent on many other factors than IQ, some of which are directly related to SES independent of IQ. Given a base level of SES, in which the East Asians had managed to develop their inherent genetic IQ to the fullest, the SES may still not be good enough to convert that IQ advantage to productivity. For example, a given household that has sufficient SES to provide good nutrition and health care, and thus ensure that its children archive their full IQ potentiality, may still not have enough resources to send them to a good school (or any school for that matter), may lack access to basic infrastructure support which handicaps the utilization of its intelligence and so on. Thus despite having the human capital, lack of the more prosaic monetary capital, may prevent them from archiving their full productivity. Thus, IQ may increase first to the maximal achievable level and only then SES increase dramatically.

It would be interesting to turn the East Asian example on its head and beg the question that if IQ is the definitive causal relation leading to SES , how do you explain the anomaly that despite high IQ's in 1950s (or for that matter Asian big brain since time immemorial) he East Asian countries did not have the corresponding productivity levels or SES. You might counter by saying that IQ -> SES causal link is mediated by factors like free markets, reforms etc to ensure that proper economic conditions are in place etc etc and only if these ideal market conditions are in place then only IQ predicts SES.

To that my simple counter-argument would be that SES -> IQ causal link also works but only in conditions when the SES is below the base level and that SES would not predict IQ absolutely. Given the same optimal SES in differnet countries, different cultures (which have different genetic pools) will have different IQ levels based on their inherent genetic capabilities.
As per this the IQ of east asians can be explained as either arising from the fact that they have already archived the SES required for full flowering; or that they still have to archive their highest IQ levels and their IQ levels are genetically vastly superior and may show more rise in future.

From Anecdotal evidence I can tell you that an average Indian has far more intelligence and creativity potential that the average IQ of 82 would suggest; most of the high SES families that have archived that high IQ migrate to US/ west and archive high SES there.
What brings down the national average is the sad fact that still a lot of Indians live below the poverty line - living in sub-optimal SES conditions that leads them to have low IQ' than what their genes or genetic makeup would suggest.

Looking forward to a fruitful discussion.
PS: Despite the tone of my original mail, I have high regards for economists in general and people like Amartya sen, Kahnman and Traversky in particular.

12:31 PM
Anonymous said...

Interesting blog entry. Has the author of it actually read the paper he is criticizing? I noticed that it costs $15 online. If not, is the author of the blog certain that the statistical methods employed by Kanazawa do not take his complaints into account implicitly? One hopes that the author is not criticizing a peer-reviewed scientific paper without having read it.

Sandy G said...

Dear Anonymous,

It would be better if, after having read the paper (otherwise by your own high standards you wouldn't have defended an article without having read it first), you would be kind enough to tell the readers of this blog how Kanazawa has taken the effects of low SES-low IQ developmentally mediated effect in consideration in his study.

You are correct in guessing that I haven't read the article (I believe in free access; so neither publish nor read material that is not freely available). I'll welcome if you or someone else could mail me the relevant portions or post them on this blog (under fair use).

As for invoking authority covertly by referring to peer-review in a prestigious journal, I would like to disclose that I haven't taken a single course or class in psychology- either in school or college- so if authority is the determinant: you can stick to reading articles in scholarly journals by those who have doctoral degrees. Blogs are not for you. Otherwise, if you believe more in open discussions and logical arguments, lets argue on facts and study method weaknesses etc and rely more on public-review to catch any discrepancies.

What I could gather from the abstract was that "The macro-level analyses show that income inequality and economic development have no effect on life expectancy at birth, infant mortality and age-specific mortality net of average intelligence quotient (IQ) in 126 countries". I take this to mean, that SES has no effect on longevity , if the effects of IQ are factored out. the 'if' is very important. This a very perverse position. This assumes that longevity is due to IQ and if IQ mediated difference in longevity data is factored out, the effcets on longevity of SES are negligible. This depends on an a priori assumption that longevity is primarily explained by IQ; and only after taking its effects into consideration, we need to look for an effect of SES on longevity.

What prevents the other, more valid and real interpretation : that SES predicts longevity and that there is little effect of IQ on longevity net of SES. Here the variation in longevity is explained by SES and after taking that into account, it would be found that, independent of IQ as a consequent of SES, IQ by itself would have little effect on longevity. the same set of data leads to this interpretation, because IQ and SES are related to a great degree and both are also related to longevity. It is just a matter of interpretation, that which is the primary cause and which an effect.


To take an absurd position, I can argue that longevity predicts/ causes both SES and IQ and reverse the causal link altogether. One can take a theoretical stand, that if people live longer , we have more labor force, blah, blah,blah... so more prodcutivity so better SES; further longevity menas that there are more wise old folks in the society and as IQ is mostly deterinmed by social influences (I do not subscribe to this, I am just taking an absurd position to show the absurdity of Kanazawa position), hence longevity of the population(more wise men) causes high IQs.

Also, please note that the above conclusion is only for the macro data he has. That interpretation is independent of his micro level data that found that self-reported health was more predicted by IQ than by SES. That micro data has nothing to do with the interpretation of the macro data. Again I don't know where he got the micro data, but I'm sure that would be a developed world population sample.
I am somewhat familiar with the macro data on which he is basing such claims, and there I do not see any reason to prefer his interpretation over other more realistic interpretations.

In the future, lets discuss merits of arguments, and not resort to ad hominem attacks over whether someone is qualified to make an argument or not. (in my opinion, by reading an abstract too, one can form a reasonable idea of what the arguments and methodologies employed are, and is thus eligible to comment)

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Magical thinking and feelings of control

A recent article in Science Magazine relates Magical thinking to feelings of control. It is an interesting paper and here is the abstract:

We present six experiments that tested whether lacking control increases illusory pattern perception,which we define as the identification of a coherent and meaningful interrelationship among a set of random or unrelated stimuli. Participants who lacked control were more likely to perceive a variety of illusory patterns, including seeing images in noise, forming illusory correlations in stock market information, perceiving conspiracies, and developing superstitions. Additionally, we demonstrated that increased pattern perception has a motivational basis by measuring the need for structure directly and showing that the causal link between lack of control and illusory pattern perception is reduced by affirming the self. Although these many disparate forms of pattern perception are typically discussed as separate phenomena, the current results suggest that there is a common motive underlying them.

More discussion of the studies can be found at Mind Hacks and Psychology Today Blog Brainstorm. 

To me, it is exciting that Magical thinking  and feelings of control are linked together. It is my thesis that Manic episodes and frank psychosis are marked by presence of Magical Thinking to a large and  non-adaptive degree.  Sometimes severe depression too causes Psychosis and I presume that Magical thinking in that case too may be increased. If so, one of the frameworks for understanding depression is that of learned helplessness paradigm , whereby mice are exposed to uncontrollable shocks and then do not even try to avoid the shocks , even after the external environment has changed and they could now possibly avoid them by correct behaviour. One explanation for psychosis in severe depression may be that feelings of lack of control rise to such a level that one starts indulging in Magical thinking and starts creating and seeing patterns that are not there and thus loosing touch with Reality. 

This raises another question of whether Manic psychosis may itself be due to the same stress and feelings of non-control, but this time not leading to Depression but Mania. We all know that bipolarity is a stress-diatheisis model and maybe whenever stress causes feelings of lack of control the bipolar people have a tendency to exaggerated magical thinking: When mood is good this may lead to Manic psychosis; while when mood is low the same magical thinking may lead to depressive psychosis. Does anyone know any literature on bipolar people being more magical thinkers? does the same reason also work well for them and endow them with creativity? Another related question would be whether bipolar people have more feelings of being out of control? And what about self-esteem, do those in Mania , who get psychosis, also suffer from lack of self-esteem and this is mediated by the role of self-esteem in protecting against magical thinking? 

    

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Language and intentionality

Michael Tomasello has a new book out titled " The origins of human communication" and the book seems to be promising, though has been a bit harshly reviewed at the Babel's Dawn. In it Tomasello proposes that a pre-requisite for language is 'a psychological infrastructure of shared intentionality'. It is based on Jean Nicod lectures and you can read a review here too.
What I am most interested is in this intentionality business. I have commented on orders of intentionality previously and this shared intentionality seems to fit the third order of intentionality that I proposed was necessary for communication.

But first for the premise of the book:

Tomasello opens his book with a consideration of the “infrastructure” that enables people to tell one another things. Apes do not have this infrastructure and the absence leads to scenes like this one:

A “whimpering chimpanzee child” is searching for its mother; the other chimps in the area are smart enough and social enough to recognize why the chimpanzee is whimpering; sometimes one of the chimps present will know where the mother is, and of course chimps have the physical ability to raise an arm point out the mother; even so, chimpanzees never help forlorn infants by pointing to the mother.

Why not?

There is a straightforward, Darwinian explanation for the ape’s mum’s-the-word behavior. Individuals don’t help non-kin. There is nothing in it for the informed adults to help the whimpering child of another. But Tomasello comes at the question from another perspective. Humans typically do help out whimpering children, even if the child is a stranger. An adult, happening upon a solitary, unknown, whimpering child is very likely to stop and ask what is wrong, take charge, and stick around until the problem is resolved. This activity strikes us as perfectly natural, normal behavior, even though it is contrary to so many of the rules in Darwin’s book. What, Tomasello wonders, is there about humans that makes such behavior easy and routine? His answer: “a psychological infrastructure of shared intentionality” [p. 12].

Thus, the premise is that pro-social behaviour and the shared intentionality underlying it are the pre-requisites for any meaningful language to evolve. And for this some tools are required.

The psychological tools Tomasello refers to are cognitive and emotional. The cognitive tools give us the understanding to engage in joint purposes and joint attention. The emotional tools provide us with the motivation for helping and sharing with others. These tools enable people to act together on a “common ground.”

Ebolles goes on further to speculate that this could be tied to Autistics' difficulty with language and I concur that the cognitive deficits related to intentionality as opposed to affective deficits empathy or mindblindness may be the roots of Autistics' language and communicative difficulties. We already know that they lack ToM to an extent and they also have communicative and social difficulties; might lack of shared intentionality, or intentionality at all or the lack of feeling of one has an intentional agent,  lie at the heart of the autism issue?

Immediately one can imagine all sorts of peculiarities that would arise in people who lack some part of these needs. Some people might have the prosocial motivation but not the cognitive ability to form a bird’s eye view. Perhaps autistic-spectrum disorder includes this difficulty. Others might have the cognitive ability, but not the prosocial motivation. There’s your sociopath, in a nutshell.

I think this common ground and 'infrastructure of shared intentionality' concept is awesome and I intend to read the book and review it soon on this blog. 

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Glutamate and classical conditioning

I had speculated in one of my earlier posts that Glutamate , GABA, Glycine and aspartate may be involved in classical conditioning / avoidance learning.  To quote:

That is it for now; I hope to back up these claims, and extend this to the rest of the 3 traits too in the near future. Some things I am toying with is either classical conditioning and avoidance learning on these higher levels; or behavior remembering (as opposed to learning) at these higher levels. Also other neurotransmitter systems like gluatamete, glycine, GABA and aspartate may be active at the higher levels. Also neuro peptides too are broadly classified in five groups so they too may have some role here. Keep guessing and do contribute to the theory if you can!!

Now, I have discovered an article that links Glutamate to classical conditioning. It is titled Reward-Predictive Cues Enhance Excitatory Synaptic Strength onto Midbrain Dopamine Neurons, and here is the abstract:

Using sensory information for the prediction of future events is essential for survival. Midbrain dopamine neurons are activated by environmental cues that predict rewards, but the cellular mechanisms that underlie this phenomenon remain elusive. We used in vivo voltammetry and in vitro patch-clamp electrophysiology to show that both dopamine release to reward predictive cues and enhanced synaptic strength onto dopamine neurons develop over the course of cue-reward learning. Increased synaptic strength was not observed after stable behavioral responding. Thus, enhanced synaptic strength onto dopamine neurons may act to facilitate the transformation of neutral environmental stimuli to salient reward-predictive cues.

Though the article itself does not talk about glutamate, and nor does this Scicurious article  on Neurotopia, commenting on the same , which focuses more on the dopamine connection, still I believe that we have a Glutamate connection here. First let us see how the artifact under discussion is indeed nothing but classical conditioning:

The basic idea is that, when you get a reward unexpectedly, you get a big spike of DA to make your brain go "sweet!" After a while, you being to recognize the cues behind the reward, and so seeing the wrapper to the candy will make your DA spike in anticipation. But it's only very recently that we've been able to see this change taking place, and there were still lots of questions as to what was happening when these changes happen.

So the authors of this study took a bunch of rats. They implanted fast scan cyclic voltammetry probes into their heads. Voltammetry is a technique that allows you to detect changes in DA levels in brain areas (in this case the nucleus accumbens, an area linked with reward) which represent groups of cells firing. So the rats had probes in their heads detecting their DA, and then they were given a stimulus light (a conditioned stimulus), a nosepoke device, and a sugar pellet. There is nothing that a rat likes more than a sugar pellet, and so there was a nice big spike in DA as it got its reward. So the rats figured out pretty quickly that, when the light came on, you stick your nose in the hole, and sugar was on the way. As they learned the conditioned stimulus, their DA spikes in response to reward SHIFTED, moving backward in time, so that they soon got a spike of DA when they saw the light, without a spike when they got the pellet. This means that the animals had learned to associate a conditioned stimulus with reward. Not only that, the DA spike was higher immediately after learning than the spike in rats who just got rewards without learning.

So, if we consider the dopamine spike as an Unconditioned Response, then what we have is a new CS-> CR pairing or classical conditioning taking place. Now, the crucial study that showed that the learning is mediated by Glutamate: (emphasis mine)

To find out whether or not excitatory synapses were in fact changing, they authors conducted electrophysiology experiments in rats that were either trained or not trained. Electrophysiology is a technique where you actually put a tiny, tiny electrode into a cell membrane. When that cell is then stimulated, you can actually WATCH it fire. It's really very cool to see. Of course all sorts of things are responsible for when a cell fires and how, but what they were looking at here were specific glutamate receptors known as AMPA and NMDA. These are two major receptors that receive glutamate currents, which are excitatory and induce cells downstream to fire. What they found was that, in animals that had been trained to a conditioned stimulus, AMPA and NMDA receptors had a much stronger influence on firing than in non-trained animals, which means that the synaptic strength on DA neurons is getting stronger as animals learn. Not only that, but cells from trained rats already exhibited long-term potentiation, a phenomenon associated with formation of things like learning and memory.

But of course, you have to make sure that glutamate is really the neurotransmitter responsible, and not just a symptom of something else changing. So they ran more rats on voltammetry and trained, and this time put a glutamate antagonist into the brain. The found that a glutamate antagonist completely blocked not only the DA shift to a conditioned stimulus, but the learning itself.

From the above it is clear that Glutamate , and the LTP that it leads to in the mid-brain neurons synapses , is crucial for Classical conditioning learning. Seems that one more puzzle is solved and another jig-jaw piece fits where it should have.

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Ig Nobles, good Science books and good banned books

This is just an FYI post regarding a few things I found worth sharing.

First on, there happened recently, an Ig noble prize ceremony and the recipients included Dan Ariely, the author of predictably irrational, for his research showing that expensive placebo medicines work better than inexpensive placebo medicines. Other interesting researches honored include research showing that coco-cola kills sperms and that playing sounds that gel while eating something (like ocean waves while eating turkey) make the food tastier. Also some research that shows that exotic dancers earn better at the peak of their fertility cycle. to me all of this seems very interesting and rational research, but let us enjoy the spirit of the Ig noble and not start using coca-cola as a contraceptive.


Next, we have a list of five great and worth reading science books by readwriteweb: While I have read GEB, the others are still on my reading list especially Stuart Koffman's book At home in the Universee and Complexity by Waldrop. would love comments from my readers as to how they have found the above books, and what additional books they would suggest.

Finally, to celebrate the banned books day, Time recently published ten most banned books and it seems I am quite perverse in my tastes because some of the best books that I have read, and which are my fondest, belong to the list. The list includes 1984, Brave New world, Lolita and The Catcher in the Rye , all of whom I simply adore. I was surprised to find children' s books like Adventures of Huckleberry Finn and Harry Potter series included there, as having read and enjoyed them, I couldn't imagine why they could have been controversial. Now, I know from where to choose my reading titles. Next on my reading list I know why the caged bird sings.

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After Social Maturity, Emotional Maturity or EI/ EQ

My last two posts have dealt with the Social Maturity theory of the developmental psychologist Robert Kegan. This post is about emotional maturity as reflected in Emotional quotient (EQ) / Emotional Intelligence (EI).

I presume that everybody is familiar with the term Emotional Intelligence, thanks to Daniel Goleman. It can be defined as:

Emotional Intelligence (EI), often measured as an Emotional Intelligence Quotient (EQ), describes an ability, capacity, skill or (in the case of the trait EI model) a self-perceived ability, to identify, assess, and manage the emotions of one's self, of others, and of groups.

As per Goleman, a person has many emotional competencies, related and measured by the above EQ, and these fall in five broad domains.

The Five Components of Emotional Intelligence

Self-awareness. The ability to recognize and understand personal moods and emotions and drives, as well as their effect on others. Hallmarks* of self-awareness include self-confidence, realistic self-assessment, and a self-deprecating sense of humor. Self-awareness depend on one's ability to monitor one's own emotion state and to correctly identify and name one's emotions.

Self-regulation.The ability to control or redirect disruptive impulses and moods, and the propensity to suspend judgment and to think before acting. Hallmarks include trustworthiness and integrity; comfort with ambiguity; and openness to change.

Motivation. A passion to work for reasons that go beyond money and status, which are external rewards. A propensity to pursue goals with energy and persistence. Hallmarks include a strong drive to achieve, optimism even in the face of failure, and organizational commitment.

Empathy. The ability to understand the emotional makeup of other people. A skill in treating people according to their emotional reactions. Hallmarks include expertise in building and retaining talent, cross-cultural sensitivity, and service to clients and customers. (In an educational context, empathy is often thought to include, or lead to, sympathy, which implies concern, or care or a wish to soften negative emotions or experiences in others.) See also Mirror Neurons.

It is important to note that empathy does not necessarily imply compassion. Empathy can be 'used' for compassionate or cruel behavior. Serial killers who marry and kill many partners in a row tend to have great emphatic skills!

Social skills. Proficiency in managing relationships and building networks, and an ability to find common ground and build rapport. Hallmarks of social skills include effectiveness in leading change, persuasiveness, and expertise building and leading teams.

These can easily be related to the Big five traits (although I am not aware of any research that does so). Below I try to correlate them to the Big five. Some of the material is taken from this source.

I) SELF-AWARENESS:

• Emotional Awareness:recognizing one's emotions and their effect
• Accurate Self-assessment: knowing one's strengths and limits
• Self-confidence: A strong sense of one's self-worth and capabilities

One can easily relate this to Neuroticism as I believe that N underlies the awareness of emotions for the first time in the child.

II) SELF-REGULATION

• Self-control: Keeping disruptive emotions and impulses in check
• Trustworthiness: Maintaining standards of honesty and integrity
• Conscientiousness: Taking responsibility for personal performance
• Adaptability: Flexibility in handling change
• Innovation: Being comfortable with novel ideas, approaches and new information

Introduction of Conscientiousness as a sub-competency in this domain makes it easy to correlate this with Conscientiousness . Also note the emphasis on impulses.

III) MOTIVATION

• Achievement drive: Striving to improve or meet a standard of excellence
• Commitment: Aligning with the goals of the group or organization
• Initiative: Readiness to act on opportunities
• Optimism: Persistence in pursuing goals despite obstacles and setbacks

This can be related to Positive emotionality or Extarversion as the emphasis seems to be on developmental of positive emotions and general energy and motivation level.

IV) EMPATHY

• Understanding others: sensing others' feelings and perspectives, taking an active interest in their concerns
• Developing others: Sensing others development needs and bolstering their abilities
• Service orientation: Anticipating, recognizing, and meeting customers' needs
• Leveraging diversity: Cultivating opportunities through different kinds of people
• Political Awareness: Reading a group's emotional currents and power relationships

This also by being named Empathy , is clearly reflective of Agreeableness. The focus for the first time shifts from self to others.

V) SOCIAL SKILLS

• Influence: Wielding effective tactics for persuasion
• Communication: Listening openly and sending convincing messages
• Conflict management: Negotiating and resolving disagreements
• Leadership: Inspiring and guiding individuals and groups
• Change Catalyst: Initiating or managing change
• Building bonds: Nurturing instrumental relationships
• Collaboration and cooperation: Working with others toward shared goals
• Team capabilities: creating group synergy in pursuing collective goals

This can be stretched to correlate to Rebelliousness-conformity/ openness/ intellect. It reflects how one uses the acquired emotional knowledge about others emotional states to advantage.

Please note that while the first three domains refer to individual's self-reflective behavior, the last tow are focused on how individual relates with others. I believe it is possible to move a notch higher and add three more domains to this - one that relate to how groups themselves function effectively in emotional settings. Note that the definition of EI contains references to how groups behave wisely, but that is not captured in above analysis by Goleman, which is confined to individuals self-reflective or other-oriented behavior, but does not cover group dynamics.

Now, many people have dismissed Goleman as Pop science, So I would like to move beyond Goleman to other people working in the same field like Mayor and Salovey and Heins. Mayor and Salovey have defined EI as :

The Four branches of EI:

1. Perception Appraisal and Expression of Emotion
2. Emotional Facilitation of Thinking
3. Understanding and Analyzing Emotions; Employing Emotional Knowledge
4. Reflective Regulation of Emotions to Promote Emotional and Intellectual Growth

Perception, Appraisal and Expression of Emotion

• Ability to identify emotion in one's physical states, feelings, and thoughts.
• Ability to identify emotions in other people, designs, artwork, etc. through language, sound, appearance, and behavior.
• Ability to express emotions accurately, and to express needs related to those feelings.
• Ability to discriminate between accurate and inaccurate, or honest vs. dishonest expressions of feeling.

Emotional Facilitation of Thinking

• Emotions prioritize thinking by directing attention to important information.
• Emotions are sufficiently vivid and available that they can be generated as aids to judgment and memory concerning feelings.
• Emotional mood swings change the individual's perspective from optimistic to pessimistic, encouraging consideration of multiple points of view.
• Emotional states differentially encourage specific problem-solving approaches such as when happiness facilitates inductive reasoning and creativity.

Understanding and Analyzing Emotions; Employing Emotional Knowledge

• Ability to label emotions and recognize relations among the words and the emotions themselves, such as the relation between liking and loving.
• Ability to interpret the meanings that emotions convey regarding relationships, such as that sadness often accompanies a loss.
• Ability to understand complex feelings: simultaneous feelings of love and hate or blends such as awe as a combination of fear and surprise.
• Ability to recognize likely transitions among emotions, such as the transition from anger to satisfaction or from anger to shame.

Reflective Regulation of Emotion to Promote Emotional and Intellectual Growth

• Ability to stay open to feelings, both those that are pleasant and those that are unpleasant.
• Ability to reflectively engage or detach from an emotion depending upon its judged informativeness or utility.
• Ability to reflectively monitor emotions in relation to oneself and others, such as recognizing how clear, typical, influential or reasonable they are.
• Ability to manage emotion in oneself and others by moderating negative emotions and enhancing pleasant ones, without repressing or exaggerating information they may convey.

I would like to modify and extend the Mayor and Salovey breakup of EI into the following eight components. It is also my thesis that they occur in the following order:

1. Emotional self-Awareness: people can differ in how much aware are they of their own internal emotional states.
2. Emotional tone/ vivacity : people can differ in how much emotion they feel for the same external / internal triggers. some may have vivid emotions while some may have bland emotions.
3. Emotional understanding/analysis/ knowledge/ monitoring : people can differ in how they interpret ones emotional states- which states they deem as close, positive, negative etc and whether they identify the states correctly.
4. Emotional self-regulation: people can differ in their abilities to regulate their emotional states: some states may be more desirable and some need to be replaced with other depending on external exigences.
5. Emotional Maturity/development/ refinement: people may differ in the extent to which they let their lives be defined by a prominent emotional/ mood state. Some may devlope their primary emotion to be Joy while others may define them primarily by sad emotions.
6. Emotional others-awareness or empathy: while the discussion till now was focused on the individual's emotions, it now moves to others' emotions. People may differ in their ability to perceive and feel the correct emotional state of others
7. Emotional communication/ labeling/ expression: People may differ in their ability to communicate their emotions to others, to label them correctly in such verbal/ non-verbal communication.
8. Emotional Integrity/ holism : people may differ in their ability to feel contradictory emotions within themselves and integrate in an overarching integral framework. they may also differ in their ability to judge the honesty or trustworthiness of others' expressed/ subtle emotions.

To me this seems a promising framework using one which could investigate the EQ/ EI conundrum. However, the above is juts a hypothesis; I believe it is testable and generates many predictions that can, and should, be tested and the theory verified or rejected accordingly. I also belive that these competencies develop in stages and follow a distinct developmental pattern. this too can be verified or rejected.

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Social maturity and self-control

In my last post I touched upon Robert Kegan's Social Maturity theory whereby as humans develop they become more and more objective and loose more and more of their subjectivity. Today I read a blog post on PsyBlog about self-control and how the techniques for self-control relies on becoming more and more abstract and more and more objective. But first the importance of self-control.

One of humanity's most useful skills, without which advanced civilizations would not exist, is being able to engage our higher cognitive functions, our self-control, to resist these temptations. Psychologists have found that self-control is strongly associated with what we label success: higher self-esteem, better interpersonal skills, better emotional responses and, perhaps surprisingly, few drawbacks at even very high levels of self-control.

Now how raising self-control is akin to becoming more objective or more socially mature. (emphasis mine)

It's not hard to see the convergence between the idea of 'psychological distance' and high-level construal. Both emphasise the idea that the more psychological or conceptual distance we can put between ourselves and the particular decision or event, the more we are able to think about it in an abstract way, and therefore the more self-control we can exert. It's all about developing a special type of objectivity.

Now for the ways in which self-control can be enhanced. Jeremy provides three ways in which we can raise our self-control (emphasis mine):

Fujita et al.'s (2006) studies, along with other similar findings reported by Fujita (2008), suggest that self-control can be increased by these related ways of thinking:

• Global processing. This means trying to focus on the wood rather than the trees: seeing the big picture and our specific actions as just one part of a major plan or purpose. For example, someone trying to eat healthily should focus on the ultimate goal and how each individual decision about what to eat contributes (or detracts) from that goal.
• Abstract reasoning. This means trying to avoid considering the specific details of the situation at hand in favour of thinking about how actions fit into an overall framework - being philosophical. Someone trying to add more self-control to their exercise regime might try to think less about the details of the exercise, and instead focus on an abstract vision of the ideal physical self, or how exercise provides a time to re-connect mind and body.
• High-level categorisation. This means thinking about high-level concepts rather than specific instances. Any long-term project, whether in business, academia or elsewhere can easily get bogged down by focusing too much on the minutiae of everyday processes and forgetting the ultimate goal. Categorising tasks or project stages conceptually may help an individual or group maintain their focus and achieve greater self-discipline.

These are just some examples of specific instances, but with a little creativity the same principles can be applied to many situations in which self-control is required. Ultimately these three ways of thinking are different ways of saying much the same thing: avoid thinking locally and specifically and practice thinking globally, objectively and abstractly, and increased self-control should follow.

To me, this looks like a very apt illustration of why developing social maturity is important. It helps in increased self control and thus better behavioral outcomes.

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